Medical Centre for Obstetrics-Gynaecology and Sexology;
The deterioration of sexual potency in the elderly male is due to complex factors and not only through the alleged decrease in testosterone levels which, after the age of 80, would represent only 20-50% of the maximum value, according to some authors (Guyton).
If we take into account these data, in which testosterone is the essential factor in determining sexual intercourse, which is undeniable, why not analyze the cause of testosterone decrease and its effects by losing testicular Leydig cells in the biological process of involution of the human body, which involves and sensitivity of cellular receptors to testosterone. Moreover, the functionality of Leydig cells is strictly controlled by the pituitary gland and brain, and in the biological process of involution, the sensitivity of brain receptor cells and of genitals, reduce their reaction to testosterone by imposing, to have the same effect, amounts much higher of testosterone in order to correct sexual dysfunction in the elderly man and to ameliorate his sexual decline. We also point out that brain neurohormones, which normally correct sexual disorders, can no longer remedy existing sexual abnormalities, the general process of cell destruction as well as apoptosis affects the neuron, too.
The cellular cycle divisions, which underlie the sexual decline associated with aging, occur according to the genetic programming for each cell, and the induced cellular morpho- functional pathology represents the associated chronic pathology (comorbidities of the elderly) that requires even surgical therapies, in order to ameliorate or to remove of sexual dysfunctions.
Keywords: testosterone, aging, biological evolution, apoptosis, GnRH, glycoproteins, peptide, second messengers, receptors.
Correspondence: Assoc. Professor Nițescu Vasile, MD,PhD, E-mail firstname.lastname@example.org, phone +40723151804