Endometriosis and the human microbioma DOI:10.37072/JCS.2020.02.02

Department of Physiology and Immunology, “Titu Maiorescu” University,
Faculty of Medicine, Bucharest, Romania
The dysbiosis of the intestinal microbiome is associated with various diseases. It is important to understand the factors that influence the intestinal microbiome and the microbiome regulation strategies to increase therapeutic responses.
Endometriosis affects about 10% of women of childbearing age. Among those affected by endometriosis, up to 50% of them suffer from chronic pelvic pain and/or infertility.
Endometriosis is characterized by inflammation and oestrogen dependence.
Endometriosis is a condition that affects fertility, creates a state of ”congestion” with excessive growth of the endometrial tissue in many other areas of the body.
The microbiota plays a role in the occurrence of endometriosis by affecting the epigenetic, immunological and/or biochemical functions of the host. Intestinal bacteria are involved in oestrogen metabolism. The oestrogen-microbiome link (or the stroboloma) helps explain where the excess oestrogen comes from.
Endometriosis appears to be associated with the increased presence of Proteobacteria, Enterobacteriaceae, Streptococcus spp. and Escherichia coli in various areas occupied by the microbiome.
Further studies are needed to analyse the association between endometriosis and microbiota.
Endometriosis is influenced by diet.
endometriosis, microbiome, endometrial microbiota

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